Gemcitabine Integrated Nano-Prodrug Carrier System
نویسندگان
چکیده
منابع مشابه
H-gemcitabine: a new gemcitabine prodrug for treating cancer.
In this report, we present a new strategy for targeting chemotherapeutics to tumors, based on targeting extracellular DNA. A gemcitabine prodrug was synthesized, termed H-gemcitabine, which is composed of Hoechst conjugated to gemcitabine. H-gemcitabine has low toxicity because it is membrane-impermeable; however, it still has high tumor efficacy because of its ability to target gemcitabine to ...
متن کاملHuman carboxylesterase-2 hydrolyzes the prodrug of gemcitabine (LY2334737) and confers prodrug sensitivity to cancer cells.
PURPOSE The oral prodrug of gemcitabine LY2334737 is cleaved systemically to gemcitabine; the mechanism responsible for hydrolysis is unknown. LY2334737 cytotoxicity was tested in the NCI-60 panel; mining of microarray expression data identified carboxylesterase (CES) as a top hydrolase candidate. Studies examined whether CES is responsible for hydrolysis and whether cellular CES expression con...
متن کاملCancer Therapy: Preclinical Human Carboxylesterase-2 Hydrolyzes the Prodrug of Gemcitabine (LY2334737) and Confers Prodrug Sensitivity to Cancer Cells
Purpose: The oral prodrug of gemcitabine LY2334737 is cleaved systemically to gemcitabine; the mechanism responsible for hydrolysis is unknown. LY2334737 cytotoxicity was tested in the NCI-60 panel; mining ofmicroarray expression data identified carboxylesterase (CES) as a top hydrolase candidate. Studies examined whether CES is responsible for hydrolysis and whether cellular CES expression con...
متن کاملLymph cancer chemotherapy: delivery of doxorubicin–gemcitabine prodrug and vincristine by nanostructured lipid carriers
PURPOSE Radiation and chemotherapy are the most common course of treatment for B-cell lymphoma. Doxorubicin (DOX), gemcitabine (GEM), and vincristine (VCR) are the commonly used antilymphoma chemotherapeutic drugs. The aim of this study is to construct a novel drug delivery system for the combination delivery of the three drugs on lymphoma. MATERIALS AND METHODS DOX-GEM prodrug was synthesize...
متن کاملIntegrated Nano-to-Millimeter (In2m) Systems
A great deal of emphasis has been placed on integrating diverse functionality into a single monolithic device for the sake of smallness and performance – but what happens when a system with diverse functionality, materials and technology can not be fabricated monolithically? The integration of systems created from dissimilar elements, especially those that vary in size by orders of magnitude is...
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ژورنال
عنوان ژورنال: Bioconjugate Chemistry
سال: 2017
ISSN: 1043-1802,1520-4812
DOI: 10.1021/acs.bioconjchem.7b00155